| 1 | Moeve Chemicals S.A.U. | Spain | Madrid | Plaza Pablo Ruiz Picasso, 1 - Torre Picasso | Madrid | 28020 | N/A | 1997 | $3,118,357,383 | 613 | N/A | N/A | A81861122 |
| 2 | Basf Española, Slu | Spain | Barcelona | Calle Can Rabia, 3 - 5 | Barcelona | 08017 | basf.***** | 1966 | $2,090,389,800 | 1,924 | N/A | N/A | B08200388 |
| 3 | Antonio Puig Sau | Spain | Hospitalet de Llobregat | Plaza Europa, 46-48 | Barcelona | 08902 | puig.***** | 1941 | $1,891,642,588 | 1,820 | N/A | N/A | A08158289 |
| 4 | Novartis Farmaceutica Sau | Spain | Barcelona | Calle Gran Via de les Corts Catalanes 764 | Barcelona | 08013 | novartis.***** | 1924 | $1,356,728,595 | 949 | N/A | N/A | A08011074 |
| 5 | Dow Chemical Iberica SL | Spain | Madrid | Calle Jose Abascal, 56 - Piso 5º | Madrid | 28003 | es.***** | 1939 | $1,344,092,668 | 734 | N/A | N/A | B48011670 |
| 6 | Bayer Hispania SL | Spain | Sant Joan Despí | Avenida Baix Llobregat, 3 -5 | Barcelona | 08970 | bayer.***** | 1966 | $913,853,477 | 561 | N/A | N/A | B08193013 |
| 7 | Boehringer Ingelheim España SA | Spain | Sant Cugat del Vallès | Calle Prat de la Riba (pg Ind Sector Turo de Can Matas) 50 | Barcelona | 08173 | avancesenrespiratorio.***** | 1958 | $808,760,095 | 1,500 | N/A | N/A | A08006470 |
| 8 | Fertiberia, SA | Spain | Madrid | Calle Agustin de Foxa, 27 - Planta 11 | Madrid | 28036 | fertiberia.***** | 1966 | $780,443,019 | 749 | N/A | N/A | A28165298 |
| 9 | Ercros, SA | Spain | Barcelona | Avenida Diagonal, 593 - 595. 10ª Planta | Barcelona | 08014 | ercros.***** | 1904 | $704,144,874 | 1,335 | N/A | N/A | A08000630 |
| 10 | Persan SA | Spain | Sevilla | Calle Pino Albar 2 | Sevilla | 41016 | persan.***** | 2004 | $693,472,280 | 686 | N/A | N/A | A91380014 |
| 11 | Lilly SA | Spain | Alcobendas | Avenida de la Industria 30 | Madrid | 28108 | lilly.***** | 1953 | $688,507,605 | 787 | N/A | N/A | A28058386 |
| 12 | Instituto Grifols SA | Spain | Parets del Vallès | Calle Can Guasch (pg Levante) 2 | Barcelona | 08150 | grifols.***** | 1987 | $686,808,066 | 1,466 | N/A | N/A | A58419326 |
| 13 | Rovi Pharma Industrial Services SA. | Spain | Alcalá de Henares | Calle Via Complutense 140 | Madrid | 28805 | msd.***** | 1979 | $634,777,637 | 1,258 | N/A | N/A | A28583912 |
| 14 | Laboratorios Cinfa SA | Spain | Sarriguren | Carretera Olaz (chipi - Pg Areta) 10 | Navarra | 31620 | cinfa.***** | 1968 | $630,551,430 | 1,431 | N/A | N/A | A31025398 |
| 15 | Iberian Lube Base Oils Company SA. | Spain | Cartagena | Poligono Industrial Valle de Escombreras, S/n | Murcia | 30350 | N/A | 2012 | $624,832,987 | 98 | N/A | N/A | A86442704 |
| 16 | Covestro SL | Spain | Barcelona | Calle Feixa Llarga 7 | Barcelona | 08040 | covestro.***** | 2002 | $609,109,200 | 518 | N/A | N/A | B62776794 |
| 17 | Laboratorios Farmaceuticos Rovi SA | Spain | Madrid | Calle Julian Camarillo 35 | Madrid | 28037 | rovi.***** | 1946 | $599,219,988 | 659 | N/A | N/A | A28041283 |
| 18 | Teva Pharma Slu | Spain | Alcobendas | Calle de Anabel Segura (ed Albatros B), 11 - Piso 1 | Madrid | 28108 | tevapharma.***** | 2004 | $597,243,737 | 900 | N/A | N/A | B83959379 |
| 19 | Basell Poliolefinas Iberica SL | Spain | Barcelona | Calle Tarragona, 161 - Modulo 3 F | Barcelona | 08014 | basell.***** | 1997 | $564,329,256 | 250 | N/A | N/A | B61392189 |
| 20 | Indorama Ventures Quimica Slu | Spain | San Roque | Poligono Industrial Guadarranque, S/n | La Coruña | 11369 | indoramaventures.***** | 2015 | $549,248,620 | 324 | N/A | N/A | B87314241 |
| 21 | Ferrer Internacional SA | Spain | Barcelona | Avenida Diagonal, 549 - 5 Pta | Barcelona | 08029 | ferrer.***** | 1940 | $546,611,774 | 1,002 | N/A | N/A | A08041162 |
| 22 | Bioiberica Sau | Spain | Palafolls | Calle Antic Cami de Tordera, 109 - 119 | Barcelona | 08389 | bioiberica.***** | 1975 | $502,457,497 | 528 | N/A | N/A | A08384190 |
| 23 | Alk Abello SA | Spain | Madrid | Calle Miguel Fleta 19 | Madrid | 28037 | alk.***** | 1999 | $498,299,885 | 343 | N/A | N/A | A82328998 |
| 24 | Akzo Nobel Coatings Slu | Spain | Barcelona | Calle Feixa Llarga (zona Franca), 14 -20 | Barcelona | 08040 | akzonobel.***** | 1968 | $491,775,659 | 1,423 | N/A | N/A | B08218158 |
| 25 | Productos Capilares L'oreal SA | Spain | Burgos | Calle Lopez Bravo (pol Industrial Villalonqu) 78 | Burgos | 09001 | loreal.***** | 1998 | $483,083,631 | 536 | N/A | N/A | A82177973 |
| 26 | Laboratorios Normon SA | Spain | Tres Cantos | Ronda de Valdecarrizo (p I Tres Cantos) 6 | Madrid | 28760 | normon.***** | 1976 | $476,189,507 | 2,935 | N/A | N/A | A28456820 |
| 27 | Henkel Iberica SA | Spain | Barcelona | Calle Bilbao, 72 -84 | Barcelona | 08005 | henkel.***** | 1941 | $469,134,510 | 1,100 | N/A | N/A | A08046799 |
| 28 | Wyeth Farma SA | Spain | San Sebastián de Los Reyes | Autovia del Norte A-1, Km 23, Desvio Algete, Km 1 | Madrid | 28700 | pfizer.***** | 1940 | $465,998,520 | 528 | N/A | N/A | A28013266 |
| 29 | Merck SL | Spain | Madrid | Calle Maria de Molina 40 | Madrid | 28006 | merck.***** | 1949 | $460,741,102 | 955 | N/A | N/A | B08070195 |
| 30 | Sociedad Española De Carburos Metalicos SA | Spain | Cornellà de Llobregat | Avenida Fama 1 | Barcelona | 08940 | carburos.***** | 1897 | $447,097,069 | 855 | N/A | N/A | A08015646 |
| 31 | Isdin SA | Spain | Barcelona | Calle Provencals, 33 - Bajo | Barcelona | 08019 | isdin.***** | 1973 | $446,054,078 | 632 | N/A | N/A | A08291924 |
| 32 | B Braun Medical SA | Spain | Rubí | Carretera Terrassa 121 | Barcelona | 08191 | micesarea.***** | 1955 | $429,624,381 | 1,375 | N/A | N/A | A08092744 |
| 33 | Bio-Oils Huelva SL | Spain | Palos de la Frontera | Poligono Nuevo Puerto (cl Gobernador Angel Horcajadas), S/n | Huelva | 21810 | bio-oils.***** | 2006 | $422,563,123 | 102 | N/A | N/A | B84688738 |
| 34 | Laboratorios Liconsa Sau | Spain | Alcalá de Henares | Calle Dulcinea, S/n | Madrid | 28805 | N/A | 1979 | $416,156,027 | 1,189 | N/A | N/A | A08576134 |
| 35 | Nippon Gases España Slu | Spain | Madrid | Calle Orense, 11 - Portal 5 | Madrid | 28020 | nippongases.***** | 1953 | $406,679,452 | 653 | N/A | N/A | B28062339 |
| 36 | Ube CORPORATION Europe Sau | Spain | Castelló de la Plana | Poligono Industrial Serrallo, S/n | Castellón | 12100 | ube.***** | 1994 | $393,651,562 | 491 | N/A | N/A | A12381158 |
| 37 | Laboratorios Hipra SA | Spain | Amer | Avenida Selva 135 | Girona | 17170 | hipra.***** | 1954 | $363,385,129 | 1,100 | N/A | N/A | A28063675 |
| 38 | Enusa Industrias Avanzadas SA SME. | Spain | Madrid | Calle Santiago Rusiñol 12 | Madrid | 28040 | enusa.***** | 1972 | $358,304,861 | 561 | N/A | N/A | A28286375 |
| 39 | Maxamcorp International SL | Spain | Madrid | Avenida Partenon (campo de Las Naciones), 16-18 5ª Planta | Madrid | 28042 | maxam.***** | 2007 | $356,802,553 | 749 | N/A | N/A | B84967587 |
| 40 | Faes Farma, SA | Spain | Leioa | Avenida Autonomia (bo. Lamiaco) 10 | Vizcaya | 48940 | faes.***** | 1933 | $351,793,784 | 743 | N/A | N/A | A48004360 |
| 41 | Italfarmaco SA | Spain | Alcobendas | Calle de San Rafael (p I Alcobendas) 3 | Madrid | 28108 | italfarmaco.***** | 1987 | $350,550,446 | 528 | N/A | N/A | A78570611 |
| 42 | Basf Sonatrach Propanchem SA | Spain | Tarragona | Carretera Nacional 340 (km 1156) | Tarragona | 43006 | basfsonatrachpropanchem.***** | 2000 | $349,061,171 | 14 | N/A | N/A | A43594951 |
| 43 | Internacional De Alcoholes SA | Spain | Tomelloso | Calle Avila 6 | Ciudad Real | 13700 | N/A | 1986 | $345,586,766 | 15 | N/A | N/A | A13035266 |
| 44 | Kern Pharma SL | Spain | Terrassa | Calle Venus (pol Ind Colon Ii) 72 | Barcelona | 08228 | kernpharma.***** | 1999 | $337,148,356 | 923 | N/A | N/A | B58296773 |
| 45 | Beiersdorf Manufacturing Tres Cantos SL | Spain | Tres Cantos | Avenida de la Industria 31 | Madrid | 28760 | nivea.***** | 2009 | $331,516,372 | 300 | N/A | N/A | B85837375 |
| 46 | Kao CORPORATION SA | Spain | Barberà del Vallès | Avenida Puig Dels Tudons (pol. Ind. Santiga) 10 | Barcelona | 08210 | kao.***** | 1987 | $329,951,418 | 445 | N/A | N/A | A58408261 |
| 47 | Astellas Pharma SA | Spain | Madrid | Paseo Castellana (ed Torre Espacio), 259 - D | Madrid | 28046 | astellas.***** | 1993 | $327,268,055 | 256 | N/A | N/A | A80461221 |
| 48 | Laboratorios Indas Sau | Spain | Pozuelo de Alarcón | Paseo del Club Deportivo (pq. Empresarial la Finca) 1 | Madrid | 28223 | indas.***** | 1965 | $314,307,240 | 570 | N/A | N/A | A45002516 |
| 49 | Esteve Quimica SA | Spain | Barcelona | Paseo Zona Franca, 109 - 4ª Planta | Barcelona | 08038 | estevequimica.***** | 1973 | $311,570,454 | 709 | N/A | N/A | A08335671 |
| 50 | Solvay Quimica Slu | Spain | Torrelavega | Avenida Alberto I, S/n | Cantabria | 39300 | solvay.***** | 1997 | $298,931,156 | 435 | N/A | N/A | B61474607 |
| 51 | Ernesto Ventos SA | Spain | Madrid | Calle Zurbaran, 9 - Lc Dcha | Madrid | 28010 | ventos.***** | 1973 | $289,823,358 | 214 | N/A | N/A | A08329344 |
| 52 | Biocarburantes De Castilla Y Leon SA | Spain | Babilafuente | Carretera Encinas Cantalapiedra (- Km 4,9) | Salamanca | 37330 | vertexbioenergy.***** | 2000 | $286,317,118 | 78 | N/A | N/A | A91079715 |
| 53 | Laboratorios Menarini SA | Spain | Badalona | Calle Alfons Xii 587 | Barcelona | 08918 | menarini.***** | 1961 | $285,516,816 | 540 | N/A | N/A | A08129181 |
| 54 | Hexcel Composites SL | Spain | Parla | Calle Bruselas (pg Ind Ciudad de Parla), 10 - 16 | Madrid | 28983 | hexcel.***** | 1986 | $280,773,662 | 212 | N/A | N/A | B78399672 |
| 55 | Laboratorio Reig Jofre SA. | Spain | Sant Joan Despí | Calle Gran Capita 10 | Barcelona | 08970 | reigjofre.***** | 1993 | $274,854,789 | 1,095 | N/A | N/A | A96184882 |
| 56 | Adisseo España SA | Spain | Burgos | Calle Merindad Castilla la Vieja (pol. Ind. Villalonquejar) 2 | Burgos | 09001 | adisseo.***** | 2002 | $272,680,806 | 150 | N/A | N/A | A09394495 |
| 57 | Laboratorios Leon Farma Sau | Spain | Villaquilambre | Calle la Vallina ((pol. Industrial Navatejera)), S/n | León | 24193 | chemopharmaceuticals.***** | 2004 | $271,022,356 | 676 | N/A | N/A | A24490864 |
| 58 | Beautyge S.L. | Spain | Cornellà de Llobregat | Calle Tirso de Molina (wtc Almeda Park) 40 | Barcelona | 08940 | revlon.***** | 1966 | $264,080,313 | 749 | N/A | N/A | B08000135 |
| 59 | R N B SL | Spain | La Pobla de Vallbona | Calle Ausias March (pg Ind la Pobla - L'Eliana), Parc. 14 | Valencia | 46185 | rnbcosmeticos.***** | 1994 | $262,261,984 | 1,000 | N/A | N/A | B96246350 |
| 60 | Venator P&A Spain SL. | Spain | Palos de la Frontera | Poligono Nuevo Puerto (cl Gobernador Angel Horcajadas), S/n | Huelva | 21810 | N/A | 1999 | $259,022,093 | 200 | N/A | N/A | B61979001 |
| 61 | Biokit SA | Spain | Lliçà D'Amunt | Avenida de Can Montcau 7 | Barcelona | 08186 | ijsgroup.***** | 1973 | $257,805,206 | 528 | N/A | N/A | A08336018 |
| 62 | Sika Sau | Spain | Alcobendas | Carretera de Fuencarral 72 | Madrid | 28108 | honestgreens.***** | 1954 | $252,786,207 | 482 | N/A | N/A | A28062842 |
| 63 | Industrias Quimicas De Badajoz SA | Spain | Guareña | Carretera Manchita (km 0 800) | Badajoz | 06470 | inquiba.***** | 1990 | $251,412,103 | 400 | N/A | N/A | A06117048 |
| 64 | Sun Chemical Sau | Spain | Alcalá de Henares | Calle Bulevar de la Habana, S/n | Madrid | 28806 | sunchemical.***** | 1989 | $248,633,779 | 444 | N/A | N/A | A79129631 |
| 65 | Clariant Iberica Produccion SA | Spain | Sant Joan Despí | Avenida Baix Llobregat 3 | Barcelona | 08970 | clariant.***** | 1994 | $245,812,447 | 250 | N/A | N/A | A60597473 |
| 66 | Air Liquide Healthcare España SL. | Spain | Madrid | Calle Orense, 34 - Piso 3º | Madrid | 28020 | airliquide.***** | 2006 | $244,134,008 | 818 | N/A | N/A | B84745801 |
| 67 | Novapet SA | Spain | Zaragoza | Paseo Independencia, 21 - Planta 3 | Zaragoza | 50001 | novapet.***** | 2004 | $232,219,256 | 420 | N/A | N/A | A50996933 |
| 68 | Al Air Liquide España, SA | Spain | Madrid | Calle Agustin de Foxa, 4 - Planta 4 | Madrid | 28036 | es.***** | 1909 | $230,788,431 | 450 | N/A | N/A | A28016814 |
| 69 | Air Liquide Iberica De Gases, Sl Unipersonal | Spain | Madrid | Calle Agustin de Foxa, 4 - Planta 4 | Madrid | 28036 | airliquide.***** | 2002 | $229,282,540 | 140 | N/A | N/A | B83479857 |
| 70 | Neuraxpharm Pharmaceuticals S.L. | Spain | Sant Joan Despí | Avenida Barcelona 69 | Barcelona | 08970 | lesvi.***** | 1967 | $229,103,052 | 528 | N/A | N/A | B08165789 |
| 71 | Quimica Del Nalon SA. | Spain | Oviedo | Avenida de Galicia, 31 - B | Asturias | 33005 | nalonchem.***** | 1943 | $227,122,973 | 450 | N/A | N/A | A33004524 |
| 72 | Innovaciones Tecnicas Aplicadas A Ceramicas Avanzadas SA | Spain | La Pobla Tornesa | Lugar Partida Rambleta, S/n | Castellón | 12191 | esmalglass-itaca.***** | 1999 | $225,908,444 | 450 | N/A | N/A | A12505293 |
| 73 | Givaudan Iberica SA | Spain | Sant Celoni | Urbanizacion Cal Batlle, S/n | Barcelona | 08470 | givaudan.***** | 1984 | $221,982,562 | 230 | N/A | N/A | A08106031 |
| 74 | The Spb Global CORPORATION Sociedad Limitada. | Spain | Cheste | Poligono Industrial Castilla 6 | Valencia | 46380 | spb.***** | 1963 | $221,665,720 | 477 | N/A | N/A | B46020541 |
| 75 | Diagnostic Grifols SA | Spain | Parets del Vallès | Calle Can Guasch (pg Ind Levant), S/n | Barcelona | 08150 | grifols.***** | 1987 | $219,941,465 | 393 | N/A | N/A | A58348517 |
| 76 | Archroma Iberica SL | Spain | El Prat de Llobregat | Calle de Cal Coracero (polg Ind Zal Prat), 46 - 56 | Barcelona | 08820 | archroma.***** | 2013 | $216,817,668 | 414 | N/A | N/A | B65983934 |
| 77 | Fresenius Kabi España SA | Spain | Barcelona | Calle Marina (torre Mapfre Vila Olimpica), 16 - 18 | Barcelona | 08005 | fresenius-kabi.***** | 1962 | $211,535,387 | 415 | N/A | N/A | A08130502 |
| 78 | Ecocarburantes Españoles SA | Spain | Cartagena | Poligono Industrial Valle de Escombreras (ctra. Nacional 343) | Murcia | 30350 | abengoa.***** | 1996 | $210,818,450 | 74 | N/A | N/A | A81406266 |
| 79 | Bioetanol Galicia SA | Spain | Teixeiro | Carretera Nacional 634 (km 664,3 Pg Teixeiro) | La Coruña | 15310 | abengoa.***** | 1997 | $207,710,434 | 75 | N/A | N/A | A36822146 |
| 80 | Industrial Farmaceutica Cantabria, SA | Spain | Villaescusa | Barrio Solia 30 | Zamora | 39690 | cantabrialabs.***** | 1942 | $207,219,064 | 556 | N/A | N/A | A39000914 |
| 81 | Sabic Innovative Plastics España SL | Spain | Cartagena | Carretera Cartagena - Alhama de Murcia (km 13) | Murcia | 30390 | geplastics.***** | 1989 | $204,137,125 | 557 | N/A | N/A | B30651681 |
| 82 | Purac Bioquimica SA | Spain | Montmeló | Calle Gran Vial, 19 -25 | Barcelona | 08160 | corbion.***** | 1947 | $202,211,389 | 214 | N/A | N/A | A08240095 |
| 83 | Drylock Technologies SL | Spain | Segovia | Calle del Gremio de Los Cordeleros 1 | Segovia | 40195 | N/A | 2016 | $200,391,387 | 350 | N/A | N/A | B87525242 |
| 84 | De Ruy Perfumes Sau | Spain | Alcalá de Guadaíra | Calle la Red Seis (pol Industrial la Red) 2 | Sevilla | 41500 | deruyperfumes.***** | 1992 | $196,696,488 | 111 | N/A | N/A | A29596624 |
| 85 | Timac Agro España SA | Spain | Orkoien | Calle C (poligono Industrial Arazuri Orcoyen) 32 | Navarra | 31160 | timacagro.***** | 1963 | $196,448,109 | 438 | N/A | N/A | A31007644 |
| 86 | Sekisui Specialty Chemicals Europe SL | Spain | Tarragona | Carretera de Valencia, S/n | Tarragona | 43006 | sekisuichemical.***** | 2009 | $196,142,964 | 89 | N/A | N/A | B43984491 |
| 87 | Exea Inversion Empresarial S.L. | Spain | Hospitalet de Llobregat | Plaza Europa, 34 - P. 18 | Barcelona | 08902 | puig.***** | 1999 | $194,523,974 | 329 | N/A | N/A | B62059498 |
| 88 | Esteve Pharmaceuticals S.A. | Spain | Barcelona | Paseo Zona Franca, 109 - 4ª Planta | Barcelona | 08038 | esteve.***** | 1936 | $194,212,369 | 528 | N/A | N/A | A08037236 |
| 89 | Eurochem Agro Iberia SL. | Spain | Barcelona | Calle Tanger, 98 - Esc B P 8 | Barcelona | 08018 | N/A | 2010 | $194,039,541 | 50 | N/A | N/A | B65452294 |
| 90 | Sandoz Industrial Products SA | Spain | Palafolls | Calle Gorg Moli D'En Puigvert (pol Mas Puigverd), 37 - 41 | Barcelona | 08389 | sandoz.***** | 1966 | $192,397,970 | 397 | N/A | N/A | A08205734 |
| 91 | Elix Polymers Slu | Spain | La Canonja | Calle de Vila-seca (pg Ind. de la Industria Quimica), S/n | Tarragona | 43110 | elix-polymers.***** | 2004 | $191,215,590 | 420 | N/A | N/A | B63508352 |
| 92 | Linde Gas España Sociedad Anonima. | Spain | Puçol | Camino Liria, S/n - Apartado de Correos, 25 | Valencia | 46530 | abellolinde.***** | 1922 | $190,622,072 | 435 | N/A | N/A | A08007262 |
| 93 | Younexa Spain SL. | Spain | Vall D'Alba | Carretera Vall D'alba-vallafames (km 4) | Castellón | 12194 | N/A | 1959 | $187,986,200 | 369 | N/A | N/A | B48027981 |
| 94 | Maxamcorp Holding SL | Spain | Madrid | Avenida Partenon (ave del Partenon), 16 - Plt 5 | Madrid | 28042 | maxam.***** | 2006 | $187,188,004 | 214 | N/A | N/A | B84598754 |
| 95 | Lacer S.A. | Spain | Cerdanyola del Vallès | Calle Els Boters 5 | Barcelona | 08290 | araipiasa.***** | 1953 | $186,029,364 | 528 | N/A | N/A | A08084238 |
| 96 | Pharma Mar SA | Spain | Colmenar Viejo | Avenida de Los Reyes (- Pg Ind la Mina) 1 | Madrid | 28770 | pharmamar.***** | 1986 | $185,043,807 | 528 | N/A | N/A | A78267176 |
| 97 | Zoetis Manufacturing & Research Spain Sociedad Limitada. | Spain | L'Hostalnou de Bianya | Carretera de Camprodon (l'Hostal Nou de Bianya), S/n | Girona | 17813 | zoetis.***** | 1955 | $181,913,208 | 326 | N/A | N/A | B17004102 |
| 98 | Reckitt Benckiser España SL | Spain | Granollers | Calle Mataro 28 | Barcelona | 08403 | rb.***** | 1921 | $181,126,326 | 185 | N/A | N/A | B48001770 |
| 99 | Esmalglass SA | Spain | Vila-real | Carretera Cv-20, Km 2,3 | Castellón | 12540 | esmalglass-itaca.***** | 1978 | $181,099,151 | 300 | N/A | N/A | A12023719 |
| 100 | Lonza Biologics Porriño SL | Spain | O Porriño | La Relba, S/n | Pontevedra | 36400 | lonza.***** | 2000 | $174,750,024 | 558 | N/A | N/A | B82550765 |